Plebani Mario, Marincola Francesco M
Department of Laboratory Medicine, University Hospital of Padova, and Center of Biomedical Research, Castelfranco Veneto TV, Italy.
Clin Chem Lab Med. 2006;44(11):1303-12. doi: 10.1515/CCLM.2006.238.
Translational research and translational medicine (referred to hereafter as translational research) are interchangeable terms that underline the pressing need to translate into practical benefits for those affected by disease the extensive investments divested by the private and public sectors in biomedical research. For people more directly involved in clinical practice (physicians, clinical laboratory professionals and patients), translational research responds to the need to accelerate the capture of benefits of research, closing the gap between what we know and what we practice. This basically means the transfer of diagnostic and therapeutic advances proven effective in large, well-conducted trials (and, therefore, evidence-based) to daily medical practice. Translational research should be regarded as a two-way road: bench to bedside, and bedside to bench. In particular, to make possible a more effective translation process, a new road map should be implemented through interaction and cooperation between basic researchers, clinicians, laboratory professionals and manufacturers. Some examples of recent developments in clinical laboratory testing, including markers of cardiovascular diseases, clinical proteomics and recombinant allergens, may explain the importance of careful evaluation of all variables that allow the introduction of such new insights into clinical practice to assure better clinical outcomes. The vital role of laboratory medicine in the delivery of safer and more effective healthcare requires more careful evaluation not only of the analytical characteristics, but also of any other variable that may affect the clinical usefulness and diagnostic performances of laboratory tests, thus allowing more accurate interpretation and utilization of laboratory information.
转化研究与转化医学（以下简称转化研究）是两个相互通用的术语，它们强调了将公共和私营部门在生物医学研究中投入的大量资金转化为对疾病患者的实际益处的迫切需求。对于更直接参与临床实践的人员（医生、临床实验室专业人员和患者）而言，转化研究满足了加速获取研究益处的需求，弥合了我们所知道的与我们所实践的之间的差距。这基本上意味着将在大规模、精心实施的试验中被证明有效的诊断和治疗进展（因此是基于证据的）应用于日常医疗实践。转化研究应被视为一条双向道路：从实验室到临床，以及从临床到实验室。特别是，为了使转化过程更有效，应通过基础研究人员、临床医生、实验室专业人员和制造商之间的互动与合作来实施新的路线图。临床实验室检测近期发展的一些例子，包括心血管疾病标志物、临床蛋白质组学和重组过敏原，可能解释了仔细评估所有变量的重要性，这些变量使得将此类新见解引入临床实践以确保更好的临床结果成为可能。检验医学在提供更安全、更有效的医疗保健方面的重要作用，不仅需要更仔细地评估分析特性，还需要评估可能影响实验室检测的临床实用性和诊断性能的任何其他变量，从而使实验室信息能够得到更准确的解读和利用。
