埃塞俄比亚布塔吉拉一项基于社区的双相情感障碍随访研究的临床结果
Clinical outcome in bipolar disorder in a community-based follow-up study in Butajira, Ethiopia.
作者信息
Fekadu A, Kebede D, Alem A, Fekadu D, Mogga S, Negash A, Medhin G, Beyero T, Shibre T
机构信息
Institute of Psychiatry, Kings College London, London, UK.
出版信息
Acta Psychiatr Scand. 2006 Dec;114(6):426-34. doi: 10.1111/j.1600-0447.2006.00825.x.
OBJECTIVE
To determine the clinical outcome of bipolar disorder in a developing country setup.
METHOD
After assessing 68 378 individuals, aged 15-49 years, in a double-sampling design in a rural community in Ethiopia, 312 patients with bipolar disorder were prospectively monitored with symptom rating scales and clinically for an average of 2.5 years.
RESULTS
Overall, 65.9% of the cohort experienced a relapse--47.8% manic, 44.3% depressive and 7.7% mixed episodes--and 31.1% had persistent illness. Female gender predicted depressive relapse, while male gender predicted manic relapse. Being on psychotropic medication was associated with remission.
CONCLUSION
This large community-based study confirms the relapsing nature of bipolar disorder and a tendency for chronicity. This may be partly because of lack of appropriate interventions in this setting; however, it may also indicate the underlying severity of the disorder irrespective of setting.
目的
确定在一个发展中国家环境中双相情感障碍的临床结局。
方法
在埃塞俄比亚一个农村社区采用双重抽样设计对68378名年龄在15至49岁的个体进行评估后，对312例双相情感障碍患者使用症状评定量表进行前瞻性监测，并进行平均2.5年的临床监测。
结果
总体而言，该队列中65.9%的患者经历了复发——47.8%为躁狂发作，44.3%为抑郁发作，7.7%为混合发作——31.1%患有持续性疾病。女性预示着抑郁复发，而男性预示着躁狂复发。服用精神药物与病情缓解相关。
结论
这项基于社区的大型研究证实了双相情感障碍的复发性本质和慢性倾向。这可能部分是由于在这种环境中缺乏适当的干预措施；然而，这也可能表明该疾病无论在何种环境下都存在潜在的严重性。
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