Grüning Thomas, Brogsitter Claudia, Khonsari Mehrdad, Jones Ivor W, Nevin Sue M, Burchert Wolfgang
Department of Nuclear Medicine, Derriford Hospital, Plymouth, UK.
Nucl Med Commun. 2006 Dec;27(12):953-7. doi: 10.1097/01.mnm.0000243368.73141.61.
Myocardial perfusion SPECT is frequently affected by artefacts related to abdominal activity. Metoclopramide has been suggested to relieve this, but two previous studies have shown conflicting results.
Ninety-five patients received 10 mg metoclopramide orally after injection of 99mTc-tetrofosmin for the stress scan and 86 patients had metoclopramide after their rest injection. A control group of 82 patients did not receive metoclopramide. Scans were evaluated visually by three readers.
Metoclopramide given before the stress scan led to abdominal activity being visually better in 16 scans, worse in 10, and unchanged in 67 scans, compared to the same patient's rest scan without metoclopramide administration. Metoclopramide administered before the rest scan resulted in abdominal activity in 11 scans being visually better, in 19 worse, and 53 scans were deemed unchanged. These differences were not significant. The number of repeat stress or rest scans was not significantly different between patients who had received metoclopramide and those who had not. The administration of metoclopramide, irrespective of whether it was given before the stress or rest scan, made no significant difference to inferior wall-to-abdomen count ratio.
Neither qualitative nor quantitative analysis showed an effect of metoclopramide on abdominal activity in myocardial perfusion SPECT.
心肌灌注单光子发射计算机断层扫描（SPECT）常受与腹部活动相关伪影的影响。有人提出胃复安可缓解此问题，但之前的两项研究结果相互矛盾。
95例患者在注射99mTc-替曲膦进行负荷扫描后口服10mg胃复安，86例患者在静息注射后服用胃复安。82例患者组成的对照组未接受胃复安。由三位阅片者对扫描图像进行视觉评估。
与同一患者未服用胃复安的静息扫描相比，负荷扫描前给予胃复安后，16例扫描图像中腹部活动在视觉上改善，10例变差，67例无变化。静息扫描前给予胃复安，11例扫描图像中腹部活动在视觉上改善，19例变差，53例无变化。这些差异无统计学意义。接受胃复安治疗的患者与未接受治疗的患者之间，重复负荷或静息扫描的次数无显著差异。无论在负荷扫描还是静息扫描前给予胃复安，对下壁与腹部计数比值均无显著影响。
无论是定性分析还是定量分析，均未显示胃复安对心肌灌注SPECT中的腹部活动有影响。
