Coli A, Bigotti G, Ferrone S
Department of Pathology, Catholic University of Sacred Heart, Rome, Italy.
Virchows Arch A Pathol Anat Histopathol. 1991;418(4):369-73. doi: 10.1007/BF01600168.
This report describes the antigenic profile of the proliferating cells of pulmonary histiocytosis X (HX) in a patient treated with chemotherapy for Hodgkin's lymphoma; the association of pulmonary HX and Hodgkin's disease has rarely been described in the literature. The histopathological diagnosis of HX was confirmed with the aid of monoclonal antibodies (mAbs) to CD4, CD1a, and polyclonal serum anti S-100 protein. The phenotype of HX cells has been analysed using a panel of mAbs against HLA class I A, B, C monomorphic determinants, locus A and B, beta 2-microglobulin, HLA class II distinct monomorphic determinants, DP, DQ, DR, intercellular adhesion molecule-1 (ICAM-1) and vitronectin receptors. Our results indicate that HX cells express HLA class I and II, including locus A, locus B and DP, DQ, DR, like their normal counterpart (represented by Langerhans cells) and detectable levels of ICAM-1 but not vitronectin receptors. We would like to stress the possibility of the association of HX and Hodgkin's lymphoma extending the immunophenotypic profile of HX cells.
本报告描述了一名接受化疗的霍奇金淋巴瘤患者肺部组织细胞增多症X（HX）增殖细胞的抗原谱；肺部HX与霍奇金病的关联在文献中鲜有描述。借助针对CD4、CD1a的单克隆抗体（mAb）以及多克隆抗S-100蛋白血清，证实了HX的组织病理学诊断。使用一组针对HLA I类A、B、C单态决定簇、A和B位点、β2-微球蛋白、HLA II类不同单态决定簇、DP、DQ、DR、细胞间黏附分子-1（ICAM-1）和玻连蛋白受体的mAb，分析了HX细胞的表型。我们的结果表明，HX细胞表达HLA I类和II类分子，包括A位点、B位点以及DP、DQ、DR，与其正常对应物（以朗格汉斯细胞为代表）相似，且可检测到ICAM-1水平，但不表达玻连蛋白受体。我们想强调HX与霍奇金淋巴瘤关联的可能性，这扩展了HX细胞的免疫表型谱。
