Hu Xianwen, Ma Qingjun, Zhang Shuyong
Beijing Institute of Biotechnology, Fengtai District, Beijing, PR China.
Biotechnol J. 2006 Nov;1(11):1215-24. doi: 10.1002/biot.200600083.
The biopharmaceutical industry, whose products are produced mainly by recombinant DNA technology, antibody technologies and cytotechnology, is the most important sector in industrial biotechnology, and is one of the most rapidly growing high-tech industries. The global market for biopharmaceuticals had been growing at annual growth rates of 15-33% over the last 8 years, and sales exceeded 55 billion dollars in 2005. This review presents an overview of the Chinese biopharmaceutical industry, listing the global top-selling biopharmaceuticals in 2005, and briefly describes the major biotech drugs approved by the Chinese State Food and Drug Administration, such as recombinant cytokines, therapeutic antibodies, recombinant vaccines, and gene therapy products.
生物制药行业主要通过重组DNA技术、抗体技术和细胞技术生产产品，是工业生物技术中最重要的领域，也是发展最为迅速的高科技产业之一。在过去八年中，全球生物制药市场以每年15%至33%的速度增长，2005年销售额超过550亿美元。本文综述了中国生物制药行业，列出了2005年全球最畅销的生物制药产品，并简要介绍了中国国家食品药品监督管理局批准的主要生物技术药物，如重组细胞因子、治疗性抗体、重组疫苗和基因治疗产品。
