van Gelder I C
Universitair Medisch Centrum Groningen, afd Cardiologie, Thoraxcentrum.
Ned Tijdschr Geneeskd. 2006 Oct 21;150(42):2294-6.
In patients with atrial fibrillation, a decision must be made whether to accept the arrhythmia (rate control) or to pursue maintenance of sinus rhythm (rhythm control). Randomized trials have shown no difference between these strategies with respect to morbidity, mortality, and quality of life. In these studies, morbidity and mortality appeared to be related predominantly to the underlying heart disease rather than to the arrhythmia itself. However, other analyses suggest that long-term sinus rhythm may improve prognosis. At any rate, complaints caused by the arrhythmia may definitely be a reason to strive for rhythm control. If pharmacological rhythm control fails, maze surgery, both in patients with lone atrial fibrillation and as concomitant surgery, is highly successful. This, however, necessitates cardiac surgery. New techniques have now emerged, including pulmonary vein isolation by means of percutaneous catheter ablation. This is less invasive and therefore nowadays the treatment of first choice if pharmacological rhythm control has failed.
对于心房颤动患者,必须决定是接受心律失常(心率控制)还是追求维持窦性心律(节律控制)。随机试验表明,在发病率、死亡率和生活质量方面,这些策略之间没有差异。在这些研究中,发病率和死亡率似乎主要与潜在的心脏病有关,而不是与心律失常本身有关。然而,其他分析表明,长期窦性心律可能改善预后。无论如何,由心律失常引起的不适肯定可能是争取节律控制的一个理由。如果药物节律控制失败,无论是孤立性心房颤动患者还是作为同期手术,迷宫手术都非常成功。然而,这需要心脏手术。现在已经出现了新技术,包括通过经皮导管消融进行肺静脉隔离。这种方法侵入性较小,因此如果药物节律控制失败,现在是首选的治疗方法。