Shabanov M A
Arkh Patol. 1990;52(12):8-13.
32 cases of a yolk sac tumour of the testis in children aged up to 5 years underwent retrospective morphological study. Foci of proliferation of activated gonocytes identical to the type A spermatogonia with clear nuclei and the type B spermatogonia characterized by a negative PAS-reaction and reaction to alpha-fetoprotein are observed in the seminiferous tubules surrounding a tumour. Besides this areas of the primordial germinogen cell generation are found among the cells lining the system of labyrinths and channels of the yolk sac tumour. A new hypothesis of the yolk sac tumour histogenesis in the child testis is put forward--namely, through the transformation of the activated gonocytes in the seminiferous tubules into their "somatic" phase, i.e. into the yolk sac elements from which they originate. Likewise, the scheme is suggested reflecting a cyclic character of the germinogenic cells in ontogenesis. This scheme allows visual representation of the process of the parthenogenetic development of germinogenic tumours.
对32例5岁以下儿童睾丸卵黄囊瘤进行了回顾性形态学研究。在肿瘤周围的生精小管中观察到与具有清晰细胞核的A型精原细胞相同的活化生殖细胞以及以PAS反应阴性和甲胎蛋白反应为特征的B型精原细胞的增殖灶。除此之外,在卵黄囊瘤的迷宫和通道系统内衬细胞中发现了原始生殖细胞生成区域。提出了儿童睾丸卵黄囊瘤组织发生的新假说——即通过生精小管中的活化生殖细胞转变为其“体细胞”阶段,即转变为它们所起源的卵黄囊成分。同样,提出了一个反映生殖细胞在个体发育中循环特征的模式。该模式可以直观呈现生殖细胞瘤孤雌生殖发育的过程。