Teshima S, Shimosato Y, Kishi K, Hirohashi S, Tome Y, Ise T, Kakizoe T, Matsumoto K
Jpn J Cancer Res. 1986 May;77(5):428-31.
The presence of testosterone in yolk sac tumor of the infant testis was investigated immunohistochemically. All 16 cases tested were positive for the hormone. The antigen-positive tumor cells were primitive mesenchymal cells and columnar cells forming small ducts, which resembled Leydig cells and Sertoli cells, respectively. These cells accounted for about 1 to 20% of tumor cells and were intermingled with typical yolk sac structures. In contrast, no yolk sac tumor of adult testis was definitely positive for the antigen. In view of its distinctive histological and immunohistochemical features and clinical behavior, yolk sac tumor in the infant testis is most likely a separate and specific entity, composed of a mixture of germ cell and sex cord stroma derivatives.
采用免疫组织化学方法对婴儿睾丸卵黄囊瘤中睾酮的存在情况进行了研究。所有检测的16例病例该激素均呈阳性。抗原阳性的肿瘤细胞为原始间充质细胞和形成小导管的柱状细胞，分别类似于睾丸间质细胞和支持细胞。这些细胞约占肿瘤细胞的1%至20%，并与典型的卵黄囊结构相互混杂。相比之下，成人睾丸卵黄囊瘤无一例抗原呈明确阳性。鉴于其独特的组织学、免疫组织化学特征及临床行为，婴儿睾丸卵黄囊瘤很可能是一个单独的特定实体，由生殖细胞和性索间质衍生物混合组成。
