Brimecombe R D, Fogel R, Limson J L
Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa.
J Agric Food Chem. 2006 Nov 15;54(23):8799-803. doi: 10.1021/jf061951k.
2,4-Dimethylaniline is a recalcitrant degradant of the pesticide amitraz and is also an industrial pollutant which is genotoxic, teratogenic and carcinogenic. The biological degradation of 2,4-dimethylaniline was examined and monitored by cyclic voltammetry. Pseudomonas species isolated from cattle dip tanks initially metabolized 2,4-dimethylaniline by oxidative deamination, following a degradation pathway via a 3-methylcatechol intermediate. The bacteria were capable of utilizing 2,4-dimethylaniline as a nitrogen source and, following deamination, as a carbon source. The formation of the metabolite, 3-methylcatechol, was monitored and confirmed by voltammetric monitoring.
2,4-二甲基苯胺是农药双甲脒的难降解降解产物，也是一种具有遗传毒性、致畸性和致癌性的工业污染物。通过循环伏安法对2,4-二甲基苯胺的生物降解进行了检测和监测。从牲畜药浴池分离出的假单胞菌属细菌最初通过氧化脱氨作用代谢2,4-二甲基苯胺，遵循一条经由3-甲基儿茶酚中间体的降解途径。这些细菌能够将2,4-二甲基苯胺用作氮源，脱氨后用作碳源。通过伏安监测对代谢产物3-甲基儿茶酚的形成进行了监测和确认。
