Evans Shelley-Ann, Al-Mosawi Ameena, Adams Rachel A, Bérubé Kelly A
School of Applied Sciences, University of Wales Institute Cardiff, Cardiff, UK.
Exp Lung Res. 2006 Sep;32(8):363-78. doi: 10.1080/01902140600959671.
Increased exposure to pollution has been implicated in cardiovascular malfunction, and although studies show a relationship between PM10 and mortality, the exact biological causes are unclear. This study investigated how compromised lungs respond to instillation of nanoparticles, and the links between exposure to nanoparticles and the subsequent effects on the blood. Instillation of diesel exhaust particles and Cabosil caused significant permeability and inflammatory changes in both bleomycin-treated and control lungs, as shown by increased lung surface protein and lung:body weight ratio. This was true in edematous and maximally repairing lungs, but without significant hematological alterations. Plasma viscosity, a renowned marker for cardiovascular disease, correlated strongly statistically with free cell numbers, type I cell marker rT140, and lung acellular protein. These correlations are a new and novel insight into the mechanisms linking air pollution to cardiovascular mortality.
接触污染增加与心血管功能障碍有关，尽管研究表明PM10与死亡率之间存在关联，但确切的生物学原因尚不清楚。本研究调查了受损肺部对纳米颗粒滴注的反应，以及接触纳米颗粒与随后对血液影响之间的联系。如肺表面蛋白和肺与体重比增加所示，柴油废气颗粒和气相二氧化硅的滴注在博来霉素治疗的肺和对照肺中均引起了显著的通透性和炎症变化。在水肿和最大程度修复的肺中都是如此，但没有明显的血液学改变。血浆粘度是心血管疾病的一个著名标志物，与游离细胞数量、I型细胞标志物rT140和肺无细胞蛋白在统计学上有很强的相关性。这些相关性为空气污染与心血管死亡率之间的联系机制提供了新的见解。
