哺乳动物中枢神经系统中的P物质受体。

Substance P receptors in mammalian central nervous system.

Segawa T, Nakata Y

Department of Pharmacology, Hiroshima University School of Medicine, Japan.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1991;98(1):147-56.

Abstract

Multiple distinct affinity states or sites of substance P (SP) receptors exist in freshly-prepared rat brain membranes. 2. Substance P receptors may couple with islet-activating protein (pertussis toxin) sensitive GTP-binding protein(s). 3. Substance P receptors may be regulated Mg2+ and Na+ in an opposite manner. 4. Some important factor(s), in addition to GTP-binding protein, appear to be involved in SP binding activity. 5. An apparent molecular weight of the SP binding site is approximately 46,000 Da.

摘要

在新制备的大鼠脑膜中存在多种不同亲和力状态或P物质（SP）受体位点。2. P物质受体可能与对胰岛激活蛋白（百日咳毒素）敏感的GTP结合蛋白偶联。3. P物质受体可能以相反的方式受Mg2+和Na+调节。4. 除GTP结合蛋白外，一些重要因素似乎也参与了SP结合活性。5. SP结合位点的表观分子量约为46,000道尔顿。