Theilmann L, Goeser T
Medizinische Universitätsklinik, Heidelberg.
Hepatogastroenterology. 1991 Feb;38(1):10-3.
A receptor for hepatitis B virus (HBV) on hepatocytes has been postulated. There is increasing evidence that the binding of the virus to the target cell surface is mediated by epitopes of the pre-S proteins of the HBV envelope. In contrast to vaccination with HBsAg, passive immunization for the prevention of HBV infection is less effective. Using antibodies against the pre-S proteins, representing the putative attachment site for HBV binding to hepatocytes, a more efficient means of protection might be achieved.
已推测出肝细胞上存在乙型肝炎病毒（HBV）受体。越来越多的证据表明，病毒与靶细胞表面的结合是由HBV包膜前S蛋白的表位介导的。与用乙肝表面抗原（HBsAg）进行疫苗接种不同，被动免疫预防HBV感染的效果较差。利用针对前S蛋白的抗体（代表HBV与肝细胞结合的假定附着位点），可能会实现一种更有效的保护手段。
