磷酸氟达拉滨在恶性黑色素瘤中的评估。一项西南肿瘤学组的研究。
Evaluation of fludarabine phosphate in malignant melanoma. A Southwest Oncology Group study.
作者信息
Kish J A, Kopecky K, Samson M K, Von Hoff D D, Fletcher W S, Kempf R A, Muggia F M
机构信息
Wayne State University Medical Center, Detroit, MI.
出版信息
Invest New Drugs. 1991 Feb;9(1):105-8. doi: 10.1007/BF00194559.
PMID:1709151
Abstract
Twenty-seven evaluable patients with advanced malignant melanoma received fludarabine phosphate in a daily x 5 injection. Initial dosing was based on the presence of previous radiation therapy. There was no response seen in these patients despite appropriate dose escalation. Myelosuppression occurred without significant sequelae.
摘要
27例可评估的晚期恶性黑色素瘤患者接受了磷酸氟达拉滨每日一次共5天的注射治疗。初始剂量根据既往放疗情况确定。尽管适当增加了剂量，但这些患者均未出现反应。发生了骨髓抑制，但无明显后遗症。
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