• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

匹苯齐莫尔治疗胰腺癌的II期研究。一项西南肿瘤协作组的研究。

Phase II study of pibenzimol in pancreatic cancer. A Southwest Oncology Group study.

作者信息

Kraut E H, Fleming T, Segal M, Neidhart J A, Behrens B C, MacDonald J

机构信息

Ohio State University Health Center, Columbus.

出版信息

Invest New Drugs. 1991 Feb;9(1):95-6. doi: 10.1007/BF00194556.

DOI:10.1007/BF00194556
PMID:1709154
Abstract

Twenty-three patients with advanced pancreatic adenocarcinoma were treated with Pibenzimol utilizing a daily intravenous schedule for five days. There were no objective responses seen. The major toxicity was pancreatic with grade 3 hyperglycemia in eleven patients. Pibenzimol is inactive in patients with advanced pancreatic adenocarcinoma.

摘要

23例晚期胰腺腺癌患者接受了匹苯齐莫尔治疗，采用每日静脉给药方案，持续5天。未观察到客观缓解。主要毒性为胰腺毒性，11例患者出现3级高血糖。匹苯齐莫尔对晚期胰腺腺癌患者无效。

相似文献

1
Phase II study of pibenzimol in pancreatic cancer. A Southwest Oncology Group study.匹苯齐莫尔治疗胰腺癌的II期研究。一项西南肿瘤协作组的研究。
Invest New Drugs. 1991 Feb;9(1):95-6. doi: 10.1007/BF00194556.
2
Phase I-II study of pibenzimol hydrochloride (NSC 322921) in advanced pancreatic carcinoma.盐酸匹苯齐莫（NSC 322921）用于晚期胰腺癌的I-II期研究。
Invest New Drugs. 1991 Feb;9(1):53-7. doi: 10.1007/BF00194545.
3
Phase II trial of merbarone in pancreatic carcinoma. A Southwest Oncology Group study.美巴龙治疗胰腺癌的II期试验。西南肿瘤协作组的一项研究。
Am J Clin Oncol. 1993 Aug;16(4):327-8. doi: 10.1097/00000421-199308000-00010.
4
Phase II evaluation of mitoxantrone in advanced pancreatic carcinoma: a Southwest Oncology Group study.米托蒽醌用于晚期胰腺癌的II期评估：一项西南肿瘤学组的研究
Invest New Drugs. 1990 Feb;8(1):77-80. doi: 10.1007/BF00216928.
5
A phase II trial of piroxantrone in adenocarcinoma of the pancreas. A Southwest Oncology Group study.
Invest New Drugs. 1993 Nov;11(4):329-31. doi: 10.1007/BF00874432.
6
A phase II study of high-dose 24 hour continuous infusion 5-FU and leucovorin and low-dose PALA for patients with advanced pancreatic adenocarcinoma: a Southwest Oncology Group Study.一项针对晚期胰腺腺癌患者的大剂量24小时持续输注5-氟尿嘧啶、亚叶酸钙及低剂量丙氨酸磷酸核糖转移酶抑制剂的II期研究：一项西南肿瘤协作组研究
Invest New Drugs. 2004 Aug;22(3):335-41. doi: 10.1023/B:DRUG.0000026261.76197.54.
7
Phase II trial of menogaril in adenocarcinoma of the pancreas. A Southwest Oncology Group study.美诺加 ril 治疗胰腺腺癌的 II 期试验。西南肿瘤协作组的一项研究。
Invest New Drugs. 1991 Feb;9(1):77-8. doi: 10.1007/BF00194550.
8
5-day vinblastine infusion for pancreatic adenocarcinoma. A phase II Southwest Oncology Group study.长春花碱5天输注治疗胰腺腺癌。西南肿瘤协作组的一项II期研究。
Invest New Drugs. 1990 May;8(2):205-6. doi: 10.1007/BF00177261.
9
Phase II evaluation of diaziquone in pancreatic carcinoma: a Southwest Oncology Group Study.重氮醌用于胰腺癌的II期评估：西南肿瘤学组研究
Cancer Treat Rep. 1987 Dec;71(12):1309-10.
10
A phase II multi-institutional trial of low-dose N-(phosphonacetyl)-L-aspartate and high-dose 5-fluorouracil as a short-term infusion in the treatment of adenocarcinoma of the pancreas. A Southwest Oncology Group study.
Cancer. 1991 Jan 15;67(2):363-6. doi: 10.1002/1097-0142(19910115)67:2<363::aid-cncr2820670208>3.0.co;2-h.

引用本文的文献

1
K3.1-dependent uptake of the cytotoxic DNA-binding dye Hoechst 33258 into cancerous but not healthy cervical cells.K3.1 依赖性摄取细胞毒性 DNA 结合染料 Hoechst 33258 进入癌细胞而非健康宫颈细胞。
J Biol Chem. 2021 Jan-Jun;296:100084. doi: 10.1074/jbc.RA120.013997. Epub 2020 Nov 23.
2
Imidazoles as potential anticancer agents.咪唑类作为潜在的抗癌药物。
Medchemcomm. 2017 Apr 13;8(9):1742-1773. doi: 10.1039/c7md00067g. eCollection 2017 Sep 1.
3
Selective permeabilization of cervical cancer cells to an ionic DNA-binding cytotoxin by activation of P2Y receptors.

本文引用的文献

1
The pleiotropic effects of 33258-Hoechst on the cell cycle in Chinese hamster cells in vitro.33258-赫斯特对体外培养的中国仓鼠细胞细胞周期的多效性作用。
Exp Cell Res. 1980 Nov;130(1):63-72. doi: 10.1016/0014-4827(80)90042-7.
2
Recent developments in the detection of deoxyribonucleic acid synthesis by 33258 Hoechst fluorescence.
J Histochem Cytochem. 1975 Jul;23(7):493-505. doi: 10.1177/23.7.1095650.
3
Condensation--inhibition by 33258-Hoechst of centromeric heterochromatin in prematurely condensed mouse chromosomes.凝聚作用——33258- Hoechst对过早凝聚的小鼠染色体着丝粒异染色质的抑制作用
通过激活P2Y受体使宫颈癌细胞对离子型DNA结合细胞毒素产生选择性通透性。
FEBS Lett. 2015 Jun 4;589(13):1498-504. doi: 10.1016/j.febslet.2015.04.044. Epub 2015 May 1.
4
New insight into the molecular mechanisms of the biological effects of DNA minor groove binders.深入了解 DNA 小沟结合物的生物学效应的分子机制。
PLoS One. 2011;6(10):e25822. doi: 10.1371/journal.pone.0025822. Epub 2011 Oct 5.
5
Hoechst-IR: an imaging agent that detects necrotic tissue in vivo by binding extracellular DNA.Hoechst-IR：一种通过结合细胞外 DNA 来体内检测坏死组织的成像剂。
Org Lett. 2010 Aug 6;12(15):3300-3. doi: 10.1021/ol100923d.
Exp Cell Res. 1979 Oct 15;123(2):406-11. doi: 10.1016/0014-4827(79)90488-9.
4
Pattern of condensation of mouse and Chinese hamster chromosomes in G2 and mitosis of 33258-Hoechst-treated cells.33258- Hoechst处理的细胞在G2期和有丝分裂期小鼠及中国仓鼠染色体的凝聚模式
Exp Cell Res. 1979 Aug;122(1):191-201. doi: 10.1016/0014-4827(79)90574-3.