Lowery Michael G, Calfin Brenda, Yeh Shu-Jen, Doan Tao, Shain Eric, Hanna Charles, Hohs Ronald, Kantor Stan, Lindberg John, Khalil Omar S
Abbott Laboratories, 100 Abbott Park Road Abbott Park, Illinois 60064, USA.
J Biomed Opt. 2006 Sep-Oct;11(5):054029. doi: 10.1117/1.2360529.
We used the effect of temperature on the localized reflectance of human skin to assess the role of noise sources on the correlation between temperature-induced fractional change in optical density of human skin (DeltaOD(T)) and blood glucose concentration [BG]. Two temperature-controlled optical probes at 30 degrees C contacted the skin, one was then cooled by -10 degrees C; the other was heated by +10 degrees C. DeltaOD(T) upon cooling or heating was correlated with capillary [BG] of diabetic volunteers over a period of three days. Calibration models in the first two days were used to predict [BG] in the third day. We examined the conditions where the correlation coefficient (R2) for predicting [BG] in a third day ranked higher than R2 values resulting from fitting permutations of randomized [BG] to the same DeltaOD(T) values. It was possible to establish a four-term linear regression correlation between DeltaOD(T) upon cooling and [BG] with a correlation coefficient higher than that of an established noise threshold in diabetic patients that were mostly females with less than 20 years of diabetes duration. The ability to predict [BG] values with a correlation coefficient above biological and body-interface noise varied between the cases of cooling and heating.
我们利用温度对人体皮肤局部反射率的影响，来评估噪声源对人体皮肤光密度的温度诱导分数变化（DeltaOD(T)）与血糖浓度[BG]之间相关性的作用。两个温度控制在30摄氏度的光学探头接触皮肤，其中一个随后被冷却10摄氏度；另一个被加热10摄氏度。冷却或加热时的DeltaOD(T)与糖尿病志愿者三天内的毛细血管[BG]相关。前两天的校准模型用于预测第三天的[BG]。我们研究了预测第三天[BG]的相关系数（R2）高于将随机[BG]排列拟合到相同DeltaOD(T)值所得到的R2值的条件。在冷却时的DeltaOD(T)与[BG]之间有可能建立一个四项线性回归相关性，其相关系数高于糖尿病患者中已确立的噪声阈值，这些患者大多为女性，糖尿病病程少于20年。冷却和加热情况下预测[BG]值的相关系数高于生物和身体界面噪声的能力有所不同。
