香豆素衍生物氯克罗孟对大鼠低血容量性失血性休克的保护作用。

Protective effect of cloricromene, a coumarine derivative, in hypovolemic hemorrhagic shock in the rat.

作者信息

Sturniolo R, Squadrito F, Campo G M, Vinci R, Calatroni A, Prosdocimi M, Caputi A P

机构信息

Institute of Pharmacology, School of Medicine, University of Messina, Italy.

出版信息

J Cardiovasc Pharmacol. 1991 Feb;17(2):261-6. doi: 10.1097/00005344-199102000-00012.

DOI:10.1097/00005344-199102000-00012

PMID:1709231

Abstract

Hypovolemic hemorrhagic shock was induced in male anesthetized rats by intermittently withdrawing blood from an iliac catheter over a period of 20 min until mean arterial pressure (MAP) fell to 30 mm Hg. Survival rate, MAP, plasma myocardial depressant factor (MDF) activity and plasma levels of both TxB2 and 6-keto PGF1 alpha were then evaluated. Cloricromene (0.5, 1, and 2 mg/kg) or an equal volume of vehicle (0.9% NaCl solution) were injected intravenously 5 min after the end of the bleeding. Hemorrhagic shocked rats showed enhanced plasma levels of MDF, TxB2 and 6-keto PGF1 alpha. All vehicle-treated rats died within 25 min. Cloricromene (1 and 2 mg/kg) given curatively significantly increased survival rate and blunted the rise in plasma MDF and TxB2. Moreover, cloricromene reversed the severe hypotension and the ST-segment elevation occurring during hemorrhagic shock. The data suggest that cloricromene exerts beneficial effects in experimental hypovolemic shock, probably reversing myocardial failure.

摘要

通过从髂静脉导管间歇性抽血20分钟，直至平均动脉压（MAP）降至30 mmHg，诱导雄性麻醉大鼠发生低血容量性失血性休克。然后评估存活率、MAP、血浆心肌抑制因子（MDF）活性以及血浆TXB2和6-酮-PGF1α水平。出血结束5分钟后，静脉注射氯克罗孟（0.5、1和2 mg/kg）或等体积的赋形剂（0.9%氯化钠溶液）。失血性休克大鼠的血浆MDF、TXB2和6-酮-PGF1α水平升高。所有接受赋形剂治疗的大鼠在25分钟内死亡。治疗性给予氯克罗孟（1和2 mg/kg）可显著提高存活率，并抑制血浆MDF和TXB2的升高。此外，氯克罗孟可逆转失血性休克期间出现的严重低血压和ST段抬高。数据表明，氯克罗孟在实验性低血容量性休克中发挥有益作用，可能是通过逆转心肌衰竭实现的。