Randle J C, Péglion J L, Renaud J F
Fondax-Groupe de Recherche Servier, Puteaux, France.
J Cardiovasc Pharmacol. 1991 Feb;17(2):348-50. doi: 10.1097/00005344-199102000-00024.
S11568, (+-)[((amino-2-ethoxy)-2-ethoxy]-methyl)-2-(dichloro-2', 3'-phenyl)-4-ethoxycarbonyl-3-methoxycarbonyl-5-methyl-6-dihydro-1,4-pyr idine HCl, is a new dihydropyridine derivative that is water soluble and relatively insensitive to light. The Ca2+ channel inhibitory activity of S11568 was tested in whole-cell patch clamp recordings from cultured embryonic chick cardiomyocytes in 40 mM Ba2(+)-containing medium that revealed T-type and L-type components of inward current through calcium channels. S11568 inhibited L-type Ca2+ current with an IC50 value near 1 microM but was without effect on the T-type barium current.
S11568，（±）[（氨基-2-乙氧基）-2-乙氧基]-甲基]-2-（二氯-2'，3'-苯基）-4-乙氧羰基-3-甲氧羰基-5-甲基-6-二氢-1,4-吡啶盐酸盐，是一种新型二氢吡啶衍生物，具有水溶性且对光相对不敏感。在含40 mM Ba2+的培养基中，从培养的胚胎鸡心肌细胞进行的全细胞膜片钳记录中测试了S11568的Ca2+通道抑制活性，该记录揭示了通过钙通道的内向电流的T型和L型成分。S11568抑制L型Ca2+电流，IC50值接近1 microM，但对T型钡电流无影响。
