实验性变应性神经炎大鼠有髓神经纤维中离子通道分布的变化

Changes of ionic channel distribution in myelinated nerve fibres from rats with experimental allergic neuritis.

作者信息

Schwarz J R, Corrette B J, Mann K, Wiethölter H

机构信息

Physiologisches Institut, Universitätskrankenhaus Eppendorf, Hamburg, F.R.G.

出版信息

Neurosci Lett. 1991 Jan 28;122(2):205-9. doi: 10.1016/0304-3940(91)90859-r.

DOI:10.1016/0304-3940(91)90859-r

PMID:1709262

Abstract

Voltage clamp experiments were performed in single myelinated nerve fibres of rats with experimental allergic neuritis (EAN). Nerve fibres from diseased animals showed a varying degree of demyelination. In fibres with extensive demyelination large K+ currents were measured. Analysis of the contribution of slow and fast K+ channels revealed that in these fibres the relative contribution of slow K+ channels was about 50% compared to about 25% in fibres acutely demyelinated as previously reported. This indicates that chronic demyelination changes the distinct distribution of ionic channels in the rat node of Ranvier.

摘要

在患有实验性变应性神经炎（EAN）的大鼠的单根有髓神经纤维上进行了电压钳实验。患病动物的神经纤维呈现出不同程度的脱髓鞘。在脱髓鞘广泛的纤维中检测到了较大的钾离子电流。对慢速和快速钾离子通道贡献的分析表明，与先前报道的急性脱髓鞘纤维中约25%相比，在这些纤维中慢速钾离子通道的相对贡献约为50%。这表明慢性脱髓鞘改变了大鼠郎飞结中离子通道的独特分布。