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[免疫功能正常患者下呼吸道感染的管理。定义、流行病学及诊断特征]

[Managing lower respiratory tract infections in immunocompetent patients. Definitions, epidemiology, and diagnostic features].

作者信息

Philippart F

机构信息

Service de réanimation polyvalente, fondation-hôpital Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France.

出版信息

Med Mal Infect. 2006 Nov-Dec;36(11-12):784-802. doi: 10.1016/j.medmal.2006.07.017. Epub 2006 Nov 7.

Abstract

Particular attention is given to lower respiratory tract infections because of their frequency and potential severity. These infections represent a major cause of death worldwide and pneumonia remains the first cause of death from infectious origin in France. Three nosological entities are usually described according to the anatomic localization of the infectious process: acute bronchitis, pneumonia, and bronchopneumonia (if the infection involves the bronchial tree and the lung parenchyma). If bronchial infection occurs within the context of a chronic respiratory tract disease, it is called acute decompensation of chronic lung disease (usually chronic obstructive pulmonary disease). The major diagnostic difficulties are to be able to confirm alveolar implication in the infectious process and to determine the pathogenic agent(s) responsible for the clinical pattern. This information is essential for subsequent care depends. Apart from clinical examination, essential in this context, only chest-X-rays can be of any help to confirm alveolar involvement in the disease process. On the contrary, the interest of systematic microbiological confirmation and its value according to various techniques and swab conditions may be questioned for the clinical diagnosis. Microbiological confirmation does not seem essential in every case. The feasibility and relevance of microbiological techniques must be determined before any decision is taken on documentation. The microbiological documentation value depends on its yield and sensitivity profile in identifying the pathogen.

摘要

由于下呼吸道感染的发生频率和潜在严重性,因此受到了特别关注。这些感染是全球范围内主要的死亡原因之一,在法国,肺炎仍然是感染性疾病导致死亡的首要原因。通常根据感染过程的解剖定位描述三种疾病实体:急性支气管炎、肺炎和支气管肺炎(如果感染累及支气管树和肺实质)。如果支气管感染发生在慢性呼吸道疾病的背景下,则称为慢性肺病急性失代偿(通常为慢性阻塞性肺疾病)。主要的诊断难点在于能够确认感染过程中肺泡是否受累,并确定导致临床表现的病原体。这些信息对于后续治疗至关重要。除了在此背景下至关重要的临床检查外,只有胸部X光检查有助于确认疾病过程中肺泡是否受累。相反,对于临床诊断而言,系统微生物学确诊的意义以及根据各种技术和拭子条件其价值可能受到质疑。微生物学确诊在每种情况下似乎并非都必不可少。在对记录做出任何决定之前,必须确定微生物学技术的可行性和相关性。微生物学记录的价值取决于其在识别病原体方面的产出率和敏感性。

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