Foley Janet, Nieto Nathan
School of Veterinary Medicine, Department of Medicine and Epidemiology, University of California, Davis, CA 95616, USA.
Trends Parasitol. 2007 Jan;23(1):3-5. doi: 10.1016/j.pt.2006.10.003. Epub 2006 Nov 7.
Anaplasma phagocytophilum is a bacterium that is transmitted by Ixodes spp. ticks, in which it resides in salivary glands. Ticks inoculate the pathogen into hosts together with an array of salivary molecules that reduce host anti-tick inflammation. Sukumaran et al. recently showed that A. phagocytophilum uses a tick salivary protein, Salp16, to enhance its uptake from the host and into the salivary gland. Occupation and exploitation of tick salivary glands have implications for the maintenance and detection of A. phagocytophilum in its vector and early pathogen interactions with its hosts.
嗜吞噬细胞无形体是一种由硬蜱属蜱虫传播的细菌，它寄生于蜱虫的唾液腺中。蜱虫将病原体与一系列能减轻宿主抗蜱炎症的唾液分子一起接种到宿主体内。苏库马兰等人最近发现，嗜吞噬细胞无形体利用蜱虫唾液蛋白Salp16来增强其从宿主进入唾液腺的摄取。占据和利用蜱虫唾液腺对嗜吞噬细胞无形体在其传播媒介中的维持和检测以及病原体与宿主的早期相互作用具有重要意义。
