Foti Robert S, Wahlstrom Jan L, Wienkers Larry C
Biochemistry/Biophysics Group, Amgen Pharmacokinetics and Drug Metabolism, Seattle, Washington 98119, USA.
Drug Metab Dispos. 2007 Feb;35(2):185-8. doi: 10.1124/dmd.106.012724. Epub 2006 Nov 8.
Herbal-based remedies are widely used as alternative treatments for a number of ailments. In addition, the use of products that contain both single and multiple herbal constituents is becoming increasingly common. The work described in this report examined the in vitro drug interaction potential for a commonly used herbal cold remedy reported to contain a mixture of eight herbal components. Experiments conducted in human liver microsomes exhibited significant inhibition (<10% of control activity remaining) of multiple cytochrome P450 (P450) isoforms, including CYP2B6, CYP2C9, and CYP2D6, by the herbal mixture. In an attempt to explain the observed P450 inhibition by the herbal mixture, individual active components were obtained and tested for inhibitory potency. Inhibition of multiple P450 activities by a single constituent, luteolin, was observed. Conversely, inhibition of a single isoform by several herbal components was noted for CYP2B6. Based on the data presented, it is concluded that mixtures of herbal components may exhibit multiple modes of P450 inhibition, indicating the potential for complex herbal-drug interaction scenarios to occur.
草药疗法被广泛用作多种疾病的替代治疗方法。此外，含有单一和多种草药成分的产品的使用也越来越普遍。本报告中描述的工作研究了一种常用的草药感冒药的体外药物相互作用潜力，据报道该感冒药含有八种草药成分的混合物。在人肝微粒体中进行的实验表明，该草药混合物对多种细胞色素P450（P450）同工酶具有显著抑制作用（剩余对照活性<10%），包括CYP2B6、CYP2C9和CYP2D6。为了解释草药混合物对P450的抑制作用，获取了各个活性成分并测试其抑制效力。观察到单一成分木犀草素对多种P450活性有抑制作用。相反，几种草药成分对CYP2B6的单一同工酶有抑制作用。根据所提供的数据，得出结论：草药成分的混合物可能表现出多种P450抑制模式，这表明可能会出现复杂的草药-药物相互作用情况。
