Aboujaoude Ramzi, Alvarez Jesus, Alvarez Manuel, Al Khan Abdullah
New Jersey Medical School, University of Medicine and Dentistry, Newark, New Jersey, USA.
Am J Perinatol. 2007 Jan;24(1):1-4. doi: 10.1055/s-2006-954955. Epub 2006 Nov 8.
Acute leukemia is a rare malignancy of pregnancy. When it develops, there are many complications to consider and management becomes exceedingly difficult. We report a case of acute myelogenous leukemia presenting as preeclampsia and fetal demise at 36 weeks of gestation. A 30-year-old multigravida presented with intrauterine fetal demise at 36 weeks' gestation, hypertension, and thrombocytopenia. The patient received platelet and packed red blood cell transfusion, with concurrent prophylactic magnesium sulfate and dexamethasone treatment. Following labor induction, the patient delivered a nonviable female fetus and suffered a stroke postpartum. Peripheral smear and flow cytometry revealed the patient had acute myeloid leukemia with prominent monocytic differentiation. The patient expired on postpartum day six. Acute leukemia during the pregnancy is associated with an unfavorable outcome.
急性白血病是妊娠期间罕见的恶性肿瘤。当它发生时，有许多并发症需要考虑，管理变得极其困难。我们报告一例急性髓系白血病病例，该病例在妊娠36周时表现为子痫前期和胎儿死亡。一名30岁的多产妇在妊娠36周时出现宫内胎儿死亡、高血压和血小板减少。患者接受了血小板和浓缩红细胞输注，同时进行了预防性硫酸镁和地塞米松治疗。引产术后，患者分娩出一名无法存活的女胎，并在产后发生中风。外周血涂片和流式细胞术显示患者患有急性髓系白血病伴显著单核细胞分化。患者在产后第六天死亡。妊娠期间的急性白血病与不良结局相关。
