用番泻苷、大黄酸和大黄素蒽酮灌注大鼠结肠。组胺释放呈浓度依赖性。

Perfusion of rat colon with sennosides, rhein and rheinanthrone. Concentration-related histamine release.

作者信息

Autore G, Caliendo G, Pepe A, Capasso F

机构信息

Department of Experimental Pharmacology, Via Domenico Montesano 49, Naples, Italy.

出版信息

Eur J Pharmacol. 1990 Nov 20;191(1):97-9. doi: 10.1016/0014-2999(90)94101-3.

DOI:10.1016/0014-2999(90)94101-3

PMID:1709407

Abstract

Rat colon perfused intraluminally in vitro and in vivo released histamine into the perfusates. Histamine release was increased by rhein 0.1-10 micrograms/ml and much more by rheinanthrone 0.1-10 micrograms/ml but not by sennosides A or B 1-10 micrograms/ml. The effect of rhein and rheinanthrone was reduced by tritoqualine 20 mg/kg. This raises the possibility that laxation by senna and its derivatives involves histamine formation.

摘要

大鼠结肠在体外和体内经腔内灌注后会向灌注液中释放组胺。大黄酸0.1 - 10微克/毫升可增加组胺释放，大黄素蒽酮0.1 - 10微克/毫升的作用更强，但番泻苷A或B 1 - 10微克/毫升则无此作用。曲托喹啉20毫克/千克可减弱大黄酸和大黄素蒽酮的作用。这增加了番泻叶及其衍生物致泻作用涉及组胺形成的可能性。