Panos George, Karveli Efthymia A, Nikolatou Ourania, Falagas Matthew E
HIV Unit, 2nd Internal Medicine Clinic, 1st IKA Hospital, Athens, Greece.
Am J Hematol. 2007 Aug;82(8):761-5. doi: 10.1002/ajh.20807.
Plasmablastic lymphoma is an aggressive subtype of diffuse large B-cell lymphoma that is mainly observed in patients with the human immunodeficiency virus (HIV) infection, and it tends to arise in the oral cavity. We present a case of an HIV-infected patient with plasmablastic lymphoma with prolonged survival. The 30-yr-old woman was found to have an oral lesion at the time of the diagnosis of HIV infection. Histological and immunochemical examination of biopsy of the oral lesion showed plasmablastic lymphoma (CD138+). She received two cycles of cyclophosphamide, vincristine, doxorubicin, and prednisolone (CHOP) that started 10 weeks after the initiation of antiretroviral therapy. The continuing pancytopenia and an adenoviral febrile infection did not permit further antineoplastic treatment. A gradual decrease of the oral lesion was noted after the second cycle of chemotherapy that led to the disappearance of the lesion 7 months later. The patient remains in complete remission 61 months after the diagnosis of plasmablastic lymphoma.
浆母细胞性淋巴瘤是弥漫性大B细胞淋巴瘤的一种侵袭性亚型，主要见于人类免疫缺陷病毒（HIV）感染患者，且往往发生于口腔。我们报告一例HIV感染的浆母细胞性淋巴瘤患者生存期延长的病例。该30岁女性在诊断HIV感染时发现口腔有病变。对口腔病变活检进行组织学和免疫化学检查显示为浆母细胞性淋巴瘤（CD138+）。她在开始抗逆转录病毒治疗10周后接受了两个周期的环磷酰胺、长春新碱、多柔比星和泼尼松龙（CHOP）化疗。持续的全血细胞减少和腺病毒发热感染使进一步的抗肿瘤治疗无法进行。化疗第二个周期后，口腔病变逐渐缩小，7个月后病变消失。该患者在诊断浆母细胞性淋巴瘤61个月后仍处于完全缓解状态。
