己酮可可碱对血小板环3',5'-腺苷单磷酸磷酸二酯酶的抑制作用。
Inhibition of platelet cyclic 3',5'-adenosine-monophosphate phosphodiesterases by pentifylline.
作者信息
Stefanovich V
出版信息
Arzneimittelforschung. 1975 May;25(5):740-1.
PMID:170944
Abstract
Pentifylline (1-hexyl-3,7-dimethylxanthine equals SK 7, the main active principle in Cosaldon) inhibits the soluble and the particulate cyclic AMP phosphodiesterases (PDE I and PDE II) from bovine platelets. I50 PDE I equals 2.0 x 10(-3)M; I50 PDE II equals 8.1 x 10(-4)M. The type of inhibition of both PDE's was non-competitive.
摘要
己酮可可碱（1-己基-3,7-二甲基黄嘌呤，等同于SK 7，为心脉宁的主要活性成分）可抑制牛血小板中的可溶性和颗粒性环磷酸腺苷磷酸二酯酶（PDE I和PDE II）。PDE I的半数抑制浓度（I50）为2.0×10⁻³M；PDE II的半数抑制浓度（I50）为8.1×10⁻⁴M。两种磷酸二酯酶的抑制类型均为非竞争性。
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