Mammano Enzo, Belluco Claudio, Sciro Manuela, Mencarelli Roberto, Agostini Marco, Michelotto Mauro, Marchet Alberto, Nitti Donato
Department of Oncological and Surgical Sciences, University of Padova, Padova, Italy.
Anticancer Res. 2006 Sep-Oct;26(5A):3547-50.
Since specific epidermal growth factor receptor (EGFR) somatic mutations have been demonstrated to influence the response to anti-EGFR therapy in non-small cell lung cancer, EGFR gene mutational analysis of different types of neoplasm is under investigation.
EGFR protein expression and gene mutations in exons 18, 19 and 21 were investigated in 49 gastric adenocarcinomas.
no specific EGFR gene mutations were detected, while EGFR positive staining was detected in 6% of the cases.
Our findings indicate that in gastric adenocarcinoma, specific EGFR gene mutations are very rare or absent and the rate of EGFR protein expression is low.
由于特定的表皮生长因子受体（EGFR）体细胞突变已被证明会影响非小细胞肺癌对抗EGFR治疗的反应，因此不同类型肿瘤的EGFR基因突变分析正在研究中。
对49例胃腺癌患者进行了EGFR蛋白表达及外显子18、19和21的基因突变检测。
未检测到特定的EGFR基因突变，而6%的病例检测到EGFR阳性染色。
我们的研究结果表明，在胃腺癌中，特定的EGFR基因突变非常罕见或不存在，EGFR蛋白表达率较低。
