Drabant Sándor, Tömlo Judit, Tóth Mária, Péterfai Eva, Klebovich Imre
EGIS Gyógyszergyár Rt. Orvostudományi Foosztály, Budapest.
Acta Pharm Hung. 2006;76(1):25-31.
Randomised, double blind placebo controlled crossover study has been performed to evaluate the effect of single dose of anxiolytic alprazolam on the cognitive function in 18 healthy male volunteers. The subject received a single dose of 0.75 mg, 1.75 mg alprazolam or placebo in randomised order. Performances on cognitive tests (immediate and delayed word recall test, digit symbol substitution test, critical fusion frequency and multiple choice reaction test) and subjective rating of the drug effect have been evaluated before and at several occasions after the administration of alprazolam or placebo. According to the results of the statistical analysis alprazolam impaired the performance in cognitive tests dose dependently and induced subjective sedation. The applied test battery proved to be capable to measure the effect of the drugs on the cognitive function in pharmacodynamic studies.
已开展一项随机、双盲、安慰剂对照的交叉研究，以评估单剂量抗焦虑药阿普唑仑对18名健康男性志愿者认知功能的影响。受试者按随机顺序接受0.75毫克、1.75毫克阿普唑仑单剂量或安慰剂。在给予阿普唑仑或安慰剂之前及之后的几个时间点，评估了认知测试（即时和延迟单词回忆测试、数字符号替换测试、临界融合频率和多项选择反应测试）的表现以及药物效果的主观评分。根据统计分析结果，阿普唑仑剂量依赖性地损害了认知测试的表现，并引起主观镇静作用。所应用的测试组合被证明能够在药效学研究中测量药物对认知功能的影响。
