Montini M, Levoni P, Ongaro A, Pagani G
Arzneimittelforschung. 1975 Aug;25(8):1311-4.
In a controlled trial 2 groups of 30 patients presenting various dislipidemic pictures were treated for 50 days with either 3,5-dihydroxy-1,4-bis-(3,4-dihydroxy-cinnamoyloxy)-cyclohexan-carbonic acid-(1) (cynarin, Listrocol) or placebo. Cynarin provied to be able to induce a significant reduction of the hypercholesteremia, the level of pre-beta-lipoproteins, the beta/alpha-lipoprotein ratio and patients' body weight. The administration of cynaria is, therefore, deemed useful in the prophylaxis and therapy of dislipidemic pictures of the arteriosclerotic disease.
在一项对照试验中,两组各30例呈现不同血脂异常情况的患者,分别用3,5 - 二羟基 - 1,4 - 双 -(3,4 - 二羟基肉桂酰氧基) - 环己烷碳酸 -(1)(洋蓟素,利斯特罗可)或安慰剂治疗50天。结果表明,洋蓟素能够显著降低高胆固醇血症、前β - 脂蛋白水平、β/α - 脂蛋白比率以及患者体重。因此,洋蓟素被认为对动脉粥样硬化疾病血脂异常情况的预防和治疗有用。