启动抗菌聚合物涂层的化学气相沉积。

Initiated chemical vapor deposition of antimicrobial polymer coatings.

作者信息

Martin T P, Kooi S E, Chang S H, Sedransk K L, Gleason K K

机构信息

Department of Chemical Engineering, Massachusetts Institute of Technology, MA, USA.

出版信息

Biomaterials. 2007 Feb;28(6):909-15. doi: 10.1016/j.biomaterials.2006.10.009. Epub 2006 Nov 13.

DOI:10.1016/j.biomaterials.2006.10.009

PMID:17095086

Abstract

The vapor phase deposition of polymeric antimicrobial coatings is reported. Initiated chemical vapor deposition (iCVD), a solventless low-temperature process, is used to form thin films of polymers on fragile substrates. For this work, finished nylon fabric is coated by iCVD with no affect on the color or feel of the fabric. Infrared characterization confirms the polymer structure. Coatings of poly(dimethylaminomethyl styrene) of up to 540 microg/cm2 were deposited on the fabric. The antimicrobial properties were tested using standard method ASTM E2149-01. A coating of 40 microg/cm2 of fabric was found to be very effective against gram-negative Escherichia coli, with over a 99.99%, or 4 log, kill in just 2 min continuing to over a 99.9999%, or 6 log, reduction in viable bacteria in 60 min. A coating of 120 microg/cm2 was most effective against the gram-positive Bacillus subtilis. Further tests confirmed that the iCVD polymer did not leach off the fabric.

摘要

报道了聚合物抗菌涂层的气相沉积。引发化学气相沉积（iCVD）是一种无溶剂低温工艺，用于在易碎基材上形成聚合物薄膜。在这项工作中，用iCVD对成品尼龙织物进行涂层处理，对织物的颜色或手感没有影响。红外表征证实了聚合物结构。在织物上沉积了高达540微克/平方厘米的聚（二甲基氨基甲基苯乙烯）涂层。使用标准方法ASTM E2149 - 01测试抗菌性能。发现40微克/平方厘米织物涂层对革兰氏阴性大肠杆菌非常有效，在仅2分钟内杀灭率超过99.99%，即4个对数级，在60分钟内活菌数持续减少超过99.9999%，即6个对数级。120微克/平方厘米的涂层对革兰氏阳性枯草芽孢杆菌最有效。进一步测试证实iCVD聚合物不会从织物上浸出。