Klenerová Vera, Krejcí Ivan, Sída Pavel, Hlinák Zdenek, Hynie Sixtus
Medical Biochemistry, Laboratory of biochemical Neuropharmacology, Charles University in Prague, Albertov 4, 128 00 Prague 2, Czech Republic.
Neurosci Lett. 2006 Dec 20;410(2):100-4. doi: 10.1016/j.neulet.2006.08.078.
Three exposures (Days 1, 2 and 3) of rats to immobilization or immobilization combined with cold induced an alteration of exploratory behavior in an open space arena. When tested 1h after both stressors exposure, rats displayed a decrease in locomotor and rearing score. The deficit disappeared when rats were tested five days later and the performance remained unchanged in trials performed on days 9, 10, 15, 22 and 29 of the study. When testing was postponed five days after the third stressor exposure, a gradual reduction of the performance developed and the deficit persisted until the last trial on Day 29. Amphetamine, in a dose of 0.3 mg/kg revealed a sensitized response to the drug in the stressed animals. The results showed short- and long-lasting behavioral consequences of the used stressors, the long-term manifestation of the sequelae being dependent on the sequence and timing of stressor exposure and open space testing.
大鼠在第1、2和3天经历三次固定或固定结合寒冷处理后，其在开放空间场地中的探究行为发生了改变。在两种应激源暴露后1小时进行测试时，大鼠的运动和直立得分降低。五天后对大鼠进行测试时，这种缺陷消失了，并且在研究的第9、10、15、22和29天进行的试验中，其表现保持不变。当在第三次应激源暴露后五天推迟测试时，表现逐渐下降，并且这种缺陷一直持续到第29天的最后一次试验。剂量为0.3mg/kg的苯丙胺在应激动物中显示出对该药物的敏感反应。结果表明，所使用的应激源会产生短期和长期的行为后果，后遗症的长期表现取决于应激源暴露和开放空间测试的顺序和时间。
