Evans J W, Singer M, Chapple C R, Macartney N, Coppinger S W, Milroy E J
Department of Urology, Middlesex Hospital, London.
Br J Urol. 1991 Apr;67(4):376-80. doi: 10.1111/j.1464-410x.1991.tb15165.x.
Haemodynamic changes were measured during routine transurethral prostatectomy (TURP). The heart rate and stroke volume fell progressively over the first 30 min of surgery, resulting in a steady reduction in cardiac output. There was a significant increase in left ventricular afterload from commencement of the procedure. These findings demonstrate that haemodynamic responses, which are not detectable using conventional methods of monitoring, occur during TURP. Increased left ventricular afterload indicates increased myocardial work and oxygen demand which could result in myocardial ischaemia. This may contribute to the increased cardiovascular morbidity and mortality which have been reported to occur after TURP. The possible underlying mechanisms are discussed.
在常规经尿道前列腺切除术（TURP）过程中测量血流动力学变化。在手术的前30分钟，心率和每搏输出量逐渐下降，导致心输出量稳步减少。从手术开始，左心室后负荷显著增加。这些发现表明，在TURP过程中会出现常规监测方法无法检测到的血流动力学反应。左心室后负荷增加表明心肌做功和需氧量增加，这可能导致心肌缺血。这可能是TURP后心血管发病率和死亡率增加的原因之一。文中讨论了可能的潜在机制。
