Sun Cheng-Hsien, Lu Cheng-Hsien, Huang Tiao-Lai
Department of Psychiatry, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Clin Neuropharmacol. 2006 Nov-Dec;29(6):368-70. doi: 10.1097/01.WNF.0000236764.23656.B4.
Blepharospasm, psychotic symptoms, and obsessive-compulsive symptoms can result from brain infarction. However, a presentation of these 3 symptoms simultaneously is rare. This report describes a 65-year-old woman who had old brain infarction and presented with these 3 symptoms for 2 years. The patient recovered after receiving a regimen of clozapine 125 mg/d for 3 months. No recurrences of symptoms were noted during a 6-month follow-up. This is the first case report demonstrating that clozapine is effective for a patient with blepharospasm, obsessive-compulsive symptoms, and psychotic symptoms presenting simultaneously. This report also reminds physicians of the possible organic causes of unusual presentations in elderly patients.
眼睑痉挛、精神病性症状和强迫症状可由脑梗死引起。然而，这三种症状同时出现的情况较为罕见。本报告描述了一名65岁女性，她有陈旧性脑梗死，出现这三种症状已达2年。该患者在接受每日125毫克氯氮平治疗3个月后康复。在6个月的随访期间未观察到症状复发。这是首例证明氯氮平对同时出现眼睑痉挛、强迫症状和精神病性症状的患者有效的病例报告。本报告还提醒医生注意老年患者异常表现可能的器质性病因。
