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Sex differences in atherosclerosis in mice with elevated phospholipid transfer protein activity are related to decreased plasma high density lipoproteins and not to increased production of triglycerides.磷脂转运蛋白活性升高的小鼠动脉粥样硬化中的性别差异与血浆高密度脂蛋白降低有关，而非与甘油三酯生成增加有关。
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Genetic variation at the phospholipid transfer protein locus affects its activity and high-density lipoprotein size and is a novel marker of cardiovascular disease susceptibility.磷脂转移蛋白基因座的遗传变异影响其活性和高密度脂蛋白大小，是心血管疾病易感性的新标志物。
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Atherogenic, enlarged, and dysfunctional HDL in human PLTP/apoA-I double transgenic mice.人PLTP/apoA-I双转基因小鼠中具有致动脉粥样硬化性、增大且功能失调的高密度脂蛋白。
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Structural basis of the lipid transfer mechanism of phospholipid transfer protein (PLTP).磷脂转运蛋白（PLTP）的脂质转移机制的结构基础。
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Phospholipid transfer protein in hemodialysis patients.血液透析患者中的磷脂转运蛋白
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Exchanging carbohydrate or protein for fat improves lipid-related cardiovascular risk profile in overweight men and women when consumed ad libitum.在超重男性和女性随意进食时，用碳水化合物或蛋白质替代脂肪可改善与脂质相关的心血管疾病风险状况。
J Investig Med. 2010 Jun;58(5):711-9. doi: 10.231/JIM.0b013e3181da4d37.

本文引用的文献

1
Absence of endogenous phospholipid transfer protein impairs ABCA1-dependent efflux of cholesterol from macrophage foam cells.内源性磷脂转运蛋白的缺失会损害巨噬细胞泡沫细胞中ABCA1依赖的胆固醇流出。
J Lipid Res. 2006 Aug;47(8):1725-32. doi: 10.1194/jlr.M600051-JLR200. Epub 2006 May 10.
2
Plasma lipid transfer proteins.血浆脂质转运蛋白。
Curr Opin Lipidol. 2006 Jun;17(3):302-8. doi: 10.1097/01.mol.0000226124.94757.ee.
3
Atheroprotective potential of macrophage-derived phospholipid transfer protein in low-density lipoprotein receptor-deficient mice is overcome by apolipoprotein AI overexpression.巨噬细胞源性磷脂转移蛋白在低密度脂蛋白受体缺陷小鼠中的抗动脉粥样硬化潜力被载脂蛋白AI过表达所抵消。
Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1572-8. doi: 10.1161/01.ATV.0000225700.43836.ae. Epub 2006 May 4.
4
Plasma phospholipid transfer protein activity is decreased in type 2 diabetes during treatment with atorvastatin: a role for apolipoprotein E?阿托伐他汀治疗2型糖尿病期间血浆磷脂转运蛋白活性降低：载脂蛋白E的作用？
Diabetes. 2006 May;55(5):1491-6. doi: 10.2337/db05-1685.
5
Plasma phospholipid transfer protein fused with green fluorescent protein is secreted by HepG2 cells and displays phosphatidylcholine transfer activity.与绿色荧光蛋白融合的血浆磷脂转运蛋白由肝癌细胞系HepG2分泌，并具有磷脂酰胆碱转运活性。
Biochem Cell Biol. 2006 Apr;84(2):117-25. doi: 10.1139/o05-168.
6
A phosphatidylinositol transfer protein alpha-dependent survival factor protects cultured primary neurons against serum deprivation-induced cell death.一种磷脂酰肌醇转移蛋白α依赖性存活因子可保护培养的原代神经元免受血清剥夺诱导的细胞死亡。
J Neurochem. 2006 May;97(3):707-15. doi: 10.1111/j.1471-4159.2006.03729.x. Epub 2006 Mar 29.
7
Altered hepatic lipid status and apolipoprotein A-I metabolism in mice lacking phospholipid transfer protein.缺乏磷脂转运蛋白的小鼠肝脏脂质状态及载脂蛋白A-I代谢的改变
Atherosclerosis. 2007 Jan;190(1):114-23. doi: 10.1016/j.atherosclerosis.2006.02.037. Epub 2006 Mar 22.
8
Active plasma phospholipid transfer protein is associated with apoA-I- but not apoE-containing lipoproteins.活性血浆磷脂转运蛋白与载脂蛋白A-I相关，但与含载脂蛋白E的脂蛋白无关。
J Lipid Res. 2006 Jun;47(6):1315-21. doi: 10.1194/jlr.M600042-JLR200. Epub 2006 Mar 6.
9
The diverse biological functions of phosphatidylinositol transfer proteins in eukaryotes.真核生物中磷脂酰肌醇转移蛋白的多种生物学功能。
Crit Rev Biochem Mol Biol. 2006 Jan-Feb;41(1):21-49. doi: 10.1080/10409230500519573.
10
Plasma apolipoprotein E concentration is an important determinant of phospholipid transfer protein activity in type 2 diabetes mellitus.血浆载脂蛋白E浓度是2型糖尿病中磷脂转运蛋白活性的重要决定因素。
Diabetes Metab Res Rev. 2006 Jul-Aug;22(4):307-12. doi: 10.1002/dmrr.616.

Genetics and molecular biology: phospholipid transfer protein in atherogenesis.

作者信息

Akopian David, Medh Jheem D

机构信息

Department of Chemistry and Biochemistry, California State University at Northridge, Northridge, California 91330-8262, USA.

出版信息

Curr Opin Lipidol. 2006 Dec;17(6):695-8. doi: 10.1097/MOL.0b013e328010a016.

DOI:10.1097/MOL.0b013e328010a016
PMID:17095914
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2767205/
Abstract
摘要