Zawaneh Peter N, Doody Anne M, Zelikin Alexander N, Putnam David
Department of Biomedical Engineeringand School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, USA.
Biomacromolecules. 2006 Nov;7(11):3245-51. doi: 10.1021/bm0605457.
Polymeric biomaterials have played an integral role in tissue engineering, biomedical devices, and targeted drug delivery. Block copolymers are especially important because their physical and chemical properties can be controlled by adjusting the ratio, size, and type of constituting blocks. Herein, the synthesis and characterization of diblock copolymers composed of poly(ethylene glycol) and a polycarbonate based on the metabolic intermediate, dihydroxyacetone, are reported. The length of the dihydroxyacetone-based block was controlled by adjusting the reactant feed ratios and initiator injection conditions. Intermediates and final products were characterized via (1)H NMR, GPC, DSC, TGA, and diffusion-ordered NMR spectroscopy. The dihydroxyacetone-based hompolymer is insoluble in water and most organic solvents, but is hydrophilic in nature. This, coupled with poly(ethylene glycol)'s solubility characteristics, allows the block copolymer to form nanoparticles in aqueous and organic anti-solvents. Dynamic light scattering and TEM results indicated the formation of spherical nanoparticles.
高分子生物材料在组织工程、生物医学装置和靶向药物递送中发挥了不可或缺的作用。嵌段共聚物尤为重要，因为其物理和化学性质可通过调整组成嵌段的比例、尺寸和类型来控制。在此，报道了由聚乙二醇和基于代谢中间体二羟基丙酮的聚碳酸酯组成的二嵌段共聚物的合成与表征。通过调整反应物进料比和引发剂注入条件来控制基于二羟基丙酮的嵌段的长度。通过¹H NMR、凝胶渗透色谱法（GPC）、差示扫描量热法（DSC）、热重分析法（TGA）和扩散排序核磁共振光谱对中间体和最终产物进行了表征。基于二羟基丙酮的均聚物不溶于水和大多数有机溶剂，但本质上具有亲水性。这与聚乙二醇的溶解性特征相结合，使得该嵌段共聚物能够在水性和有机反溶剂中形成纳米颗粒。动态光散射和透射电子显微镜（TEM）结果表明形成了球形纳米颗粒。
