He Rongjun, Ching Shi Min, Lam Yulin
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
J Comb Chem. 2006 Nov-Dec;8(6):923-8. doi: 10.1021/cc060092+.
A traceless solid-phase route to substituted xanthines, based on the late-stage pyrimidine ring closure, has been developed. This method is especially useful for the preparation of xanthines containing a variety of substituents at the N1, N3, N7, and C8 positions in an unambiguous manner. A representative set of 22 compounds was prepared.
