阿尔茨海默病与2型糖尿病：胆碱酯酶之间的联系？
Alzheimer's disease and type 2 diabetes mellitus: the cholinesterase connection?
作者信息
Sridhar Gumpeny Ramachandra, Thota Hanuman, Allam Appa Rao, Suresh Babu Changalasetty, Siva Prasad Akula, Divakar Ch
机构信息
Endocrine and Diabetes Centre, 15-12-16 Krishnanagar, Visakhapatnam 530 002, India.
出版信息
Lipids Health Dis. 2006 Nov 11;5:28. doi: 10.1186/1476-511X-5-28.
Alzheimer's disease and type 2 diabetes mellitus tend to occur together. We sought to identify protein(s) common to both conditions that could suggest a possible unifying pathogenic role. Using human neuronal butyrylcholinesterase (AAH08396.1) as the reference protein we used BLAST Tool for protein to protein comparison in humans. We found three groups of sequences among a series of 12, with an E-value between 0-12, common to both Alzheimer's disease and diabetes: butyrylcholinesterase precursor K allele (NP_000046.1), acetylcholinesterase isoform E4-E6 precursor (NP_000656.1), and apoptosis-related acetylcholinesterase (1B41|A). Butyrylcholinesterase and acetylcholinesterase related proteins were found common to both Alzheimer's disease and diabetes; they may play an etiological role via influencing insulin resistance and lipid metabolism.
阿尔茨海默病和2型糖尿病往往同时发生。我们试图找出这两种病症共有的蛋白质，这些蛋白质可能提示一种潜在的统一致病作用。以人类神经元丁酰胆碱酯酶（AAH08396.1）作为参考蛋白，我们使用BLAST工具在人类中进行蛋白质与蛋白质的比较。在一系列12个序列中，我们发现了三组序列，其E值在0至12之间，阿尔茨海默病和糖尿病均有：丁酰胆碱酯酶前体K等位基因（NP_000046.1）、乙酰胆碱酯酶同工型E4 - E6前体（NP_000656.1）以及凋亡相关乙酰胆碱酯酶（1B41|A）。发现丁酰胆碱酯酶和乙酰胆碱酯酶相关蛋白在阿尔茨海默病和糖尿病中均存在；它们可能通过影响胰岛素抵抗和脂质代谢发挥病因学作用。
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