Eyster Kathleen M
Sanford School of Medicine of the University of South Dakota, Division of Basic Biomedical Sciences, Vermillion, SD 57069, USA.
Biochem Pharmacol. 2007 May 15;73(10):1511-9. doi: 10.1016/j.bcp.2006.10.006. Epub 2006 Oct 13.
Signal transduction is a dynamic field in which established pathways evolve and new pathways emerge. The purpose of this commentary is to highlight new paradigms of signal transduction that have developed over the past few years. This discussion proposes a third member of the generic models of membrane receptors in addition to the 7-transmembrane pass receptor and the enzyme-linked receptor: the non-enzymatic nucleating receptor. Also discussed are the new paradigms of signal transduction by proteolysis which includes signaling by Notch, signaling through the Hedgehog and Wnt pathways, signaling through histidine phosphorylation, and reactive oxygen species in signal transduction.
信号转导是一个动态领域，其中既定的信号通路不断演变，新的信号通路不断涌现。本述评的目的是突出过去几年中发展起来的信号转导新范式。除了7次跨膜受体和酶联受体之外，本讨论还提出了膜受体通用模型的第三个成员：非酶成核受体。还讨论了蛋白水解信号转导的新范式，包括Notch信号转导、通过Hedgehog和Wnt信号通路的信号转导、通过组氨酸磷酸化的信号转导以及信号转导中的活性氧。
