Bindu B, Alladi P A, Mansooralikhan B M, Srikumar B N, Raju T R, Kutty B M
Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore, India.
Neuroscience. 2007 Jan 19;144(2):412-23. doi: 10.1016/j.neuroscience.2006.09.057. Epub 2006 Nov 9.
Environmental enrichment promotes structural and behavioral plasticity in the adult brain. We have evaluated the efficacy of enriched environment on the dendritic morphology and brain-derived neurotrophic factor (BDNF) expression in the hippocampus of ventral subicular-lesioned rats. Bilateral ventral subicular lesion has significantly reduced the dendritic architecture and spine density of hippocampal pyramidal neurons. The lesioned rats exposed to enriched housing for 10 days showed a significant degree of morphological plasticity in terms of enhanced dendritic branching and spine density. However, the BDNF expression in the hippocampus remained unchanged following subicular lesion and following environmental enrichment. We suggest the participation of other neurotrophic factors in mediating the synaptic plasticity events following exposure to environmental enrichment in ventral subicular-lesioned rats.
环境富集促进成年大脑的结构和行为可塑性。我们评估了富集环境对腹侧海马下托损伤大鼠海马区树突形态和脑源性神经营养因子（BDNF）表达的影响。双侧腹侧海马下托损伤显著降低了海马锥体细胞的树突结构和棘密度。暴露于富集环境10天的损伤大鼠在树突分支和棘密度增强方面表现出显著程度的形态可塑性。然而，海马下托损伤后以及环境富集后，海马中的BDNF表达保持不变。我们认为在腹侧海马下托损伤大鼠暴露于环境富集后，其他神经营养因子参与介导了突触可塑性事件。
