Suradhat S, Damrongwatanapokin S, Thanawongnuwech R
Chulalongkorn University, Henri-Dunant Road, Bangkok 10330, Thailand.
Vet Microbiol. 2007 Jan 17;119(1):1-9. doi: 10.1016/j.vetmic.2006.10.003. Epub 2006 Oct 12.
Classical swine fever (CSF) or hog cholera, caused by the classical swine fever virus (CSFV), is one of the most important viral diseases that cause serious economic loss to the swine industry worldwide. During the past 5 years, several techniques for measuring porcine cell-mediated immunity (CMI) were applied, in conjunction with other conventional techniques, to study factors that influence the induction of CSFV-specific immunity. Information, obtained from a series of experiments, demonstrated cell-mediated immune responses in providing protective immunity against CSF infection. Although it has been confirmed that commercially available modified live CSF vaccines are able to induce complete protection in vaccinated pigs, several factors including maternal immunity, the age of primary vaccination, vaccination protocol and complications caused by other pathogens, can greatly affect the effectiveness of CSF vaccines in the field.
经典猪瘟（CSF）或猪霍乱，由经典猪瘟病毒（CSFV）引起，是导致全球养猪业严重经济损失的最重要病毒性疾病之一。在过去5年中，几种用于测量猪细胞介导免疫（CMI）的技术与其他传统技术相结合，用于研究影响CSFV特异性免疫诱导的因素。从一系列实验中获得的信息表明，细胞介导的免疫反应可提供针对CSF感染的保护性免疫。尽管已经证实市售的改良活CSF疫苗能够在接种疫苗的猪中诱导完全保护，但包括母源免疫、初次接种年龄、接种方案以及其他病原体引起的并发症等几个因素，会极大地影响CSF疫苗在实际应用中的效果。
