Ito Shigeo, Suhara Tetsuya, Ito Hiroshi, Yasuno Fumihiko, Ichimiya Tetsuya, Takano Akihiro, Maehara Taketoshi, Matsuura Masato, Okubo Yoshiro
Section of Psychiatry and Behavioral Science, Graduate School of Tokyo Medical and Dental University, Tokyo, Japan.
Epilepsy Res. 2007 Jan;73(1):111-8. doi: 10.1016/j.eplepsyres.2006.09.003. Epub 2006 Nov 9.
The possible involvement of the brain 5-HT(1A) receptor in epilepsy has been indicated in animal seizure models. Recent in vivo neuroimaging studies demonstrated decreased 5-HT(1A) receptor binding in epilepsy. Using positron emission tomography (PET) with [(11)C]WAY100635, we investigated 5-HT(1A) receptor binding in patients with mesial temporal lobe epilepsy and aimed to clarify the involvement of the brain 5-HT(1A) receptor system in epilepsy.
PET measurements with [(11)C]WAY100635 were performed on 23 healthy volunteers and 13 patients who were diagnosed with mesial temporal lobe epilepsy based on clinical symptoms and electroencephalogram (EEG) findings. They had non-lesional mesial temporal lobe epilepsy with unilateral EEG foci and no hippocampal atrophy on magnetic resonance imaging. The binding potential (BP) of [(11)C]WAY100635 was calculated by the reference tissue model method. Data were analyzed for each region of interest (ROI) and on a voxel-by-voxel basis by statistical parametric mapping (SPM) system.
ROI and voxel-based analyses consistently demonstrated that 5-HT(1A) receptor BP was significantly decreased in the temporal lobe, hippocampus and amygdala on the ipsilateral side of the EEG focus compared to controls. In addition, decreased 5-HT(1A) receptor BP was also observed on the contralateral side of the amygdala.
5-HT(1A) receptor binding in patients with mesial temporal lobe epilepsy decreased predominantly in the ipsilateral mesial temporal lobe structures but also in the contralateral side. The imaging of 5-HT(1A) receptor binding by PET detects functional changes of the limbic system in mesial temporal lobe epilepsy, proving to be a sensitive and useful method.
动物癫痫模型已表明大脑5-羟色胺（5-HT）1A受体可能参与癫痫。最近的体内神经影像学研究表明癫痫中5-HT1A受体结合减少。我们使用[（11）C]WAY100635正电子发射断层扫描（PET）研究了内侧颞叶癫痫患者的5-HT1A受体结合情况，旨在阐明大脑5-HT1A受体系统在癫痫中的作用。
对23名健康志愿者和13名根据临床症状和脑电图（EEG）结果诊断为内侧颞叶癫痫的患者进行了[（11）C]WAY100635的PET测量。他们患有非病变性内侧颞叶癫痫，脑电图有单侧病灶，磁共振成像显示无海马萎缩。通过参考组织模型方法计算[（11）C]WAY100635的结合潜能（BP）。数据通过感兴趣区（ROI）进行分析，并使用统计参数映射（SPM）系统逐体素分析。
基于ROI和体素的分析一致表明，与对照组相比，脑电图病灶同侧的颞叶、海马和杏仁核中5-HT1A受体BP显著降低。此外，在杏仁核的对侧也观察到5-HT1A受体BP降低。
内侧颞叶癫痫患者的5-HT1A受体结合主要在同侧内侧颞叶结构中降低，但在对侧也有降低。PET对5-HT1A受体结合的成像检测到内侧颞叶癫痫边缘系统的功能变化，证明是一种敏感且有用的方法。
