Hofmann Silke C, Technau Kristin, Müller Antonia M S, Lübbert Michael, Bruckner-Tuderman Leena
Department of Dermatology, University of Freiburg Freiburg, Germany.
J Am Acad Dermatol. 2007 May;56(5 Suppl):S68-72. doi: 10.1016/j.jaad.2006.02.059. Epub 2006 Aug 28.
Hypereosinophilic syndrome is a myeloproliferative disorder defined by unexplained, persistent hypereosinophilia with cutaneous or systemic involvement. We describe a patient with coexistence of hypereosinophilic syndrome and bullous pemphigoid. Treatment with the novel tyrosine kinase inhibitor imatinib mesylate resulted in durable remission of hypereosinophilia and skin lesions.
高嗜酸性粒细胞综合征是一种骨髓增殖性疾病，其定义为原因不明的持续性嗜酸性粒细胞增多并伴有皮肤或全身受累。我们描述了一位同时患有高嗜酸性粒细胞综合征和大疱性类天疱疮的患者。使用新型酪氨酸激酶抑制剂甲磺酸伊马替尼治疗后，嗜酸性粒细胞增多和皮肤病变得到了持久缓解。
