大剂量静脉注射丙种球蛋白治疗新生儿血型不合免疫性溶血性黄疸。
High-dose intravenous gammaglobulin therapy for neonatal immune haemolytic jaundice due to blood group incompatibility.
作者信息
Sato K, Hara T, Kondo T, Iwao H, Honda S, Ueda K
机构信息
Department of Neonatology, Medical Center for Sick Children and Infectious Disease, Fukuoka, Japan.
出版信息
Acta Paediatr Scand. 1991 Feb;80(2):163-6. doi: 10.1111/j.1651-2227.1991.tb11828.x.
Three newborn infants who developed hyperbilirubinemia due to blood group incompatibility were treated with high-dose gammaglobulin. Hyperbilirubinemia was caused by Rhesus (Rh) incompatibility (anti-E + anti-c) in Infant 1 and ABO incompatibility (anti-B) in Infants 2 and 3. Hyperbilirubinemia was refractory to conventional phototherapy but responded well to intravenous gammaglobulin (IVGG) at a dose of 1 g/kg in all infants. No adverse effects were observed. These findings suggest that high-dose IVGG may be useful in the treatment of hyperbilirubinemia due to isoimmune haemolytic disease resistant to phototherapy.
三名因血型不合而发生高胆红素血症的新生儿接受了大剂量丙种球蛋白治疗。婴儿1的高胆红素血症由恒河猴（Rh）血型不合（抗-E + 抗-c）引起，婴儿2和3的高胆红素血症由ABO血型不合（抗-B）引起。常规光疗对高胆红素血症无效，但所有婴儿静脉注射丙种球蛋白（IVGG），剂量为1 g/kg时，反应良好。未观察到不良反应。这些发现表明，大剂量IVGG可能有助于治疗对光疗耐药的同族免疫性溶血病引起的高胆红素血症。
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