流感疫苗接种对主要特定病因死亡率的影响。
Impact of influenza vaccination on major cause-specific mortality.
作者信息
Wang Chong-Shan, Wang Shan-Tair, Lai Ching-Te, Lin Li-Jen, Chou Pesus
机构信息
Community Medicine Research Centre and Institute of Public Health, National Yang-Ming University, Taipei, Taiwan.
出版信息
Vaccine. 2007 Jan 26;25(7):1196-203. doi: 10.1016/j.vaccine.2006.10.015. Epub 2006 Oct 25.
The efficacy of influenza vaccination is not well understood for major cause-specific mortality except pneumonia. For 10 months we followed the mortality data of 35,637 vaccinated elderly (>65 years old) in a county with 102,698 elderly in southern Taiwan. A multivariate Cox model showed that vaccination was significantly associated with lower mortality for all causes, [hazards ratio (HR)=0.56], stroke (HR=0.35), renal disease (HR=0.40), diabetes mellitus (HR=0.45), pneumonia (HR=0.47), COPD (HR=0.55), malignancy (HR=0.74), and heart diseases (HR=0.78), p<0.05. Influenza vaccination was strongly associated with reducing major cause-specific mortality.
除肺炎外，流感疫苗对主要特定病因死亡率的疗效尚不清楚。在台湾南部一个有102,698名老年人的县，我们对35,637名接种疫苗的老年人（>65岁）的死亡率数据进行了为期10个月的跟踪。多变量Cox模型显示，接种疫苗与所有原因导致的较低死亡率显著相关，[风险比（HR）=0.56]，中风（HR=0.35）、肾病（HR=0.40）、糖尿病（HR=0.45）、肺炎（HR=0.47）、慢性阻塞性肺疾病（HR=0.55）、恶性肿瘤（HR=0.74）和心脏病（HR=0.78），p<0.05。流感疫苗接种与降低主要特定病因死亡率密切相关。
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