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因年龄因素扩大供体标准:一项有回报的努力。

Expanded donor criteria due to age: an effort rewarded.

作者信息

Daga D, Frutos M A, Séller G, Ruiz P, Mansilla J J, Carballo M

机构信息

Hospital Universitario Virgen de la Victoria, Malaga, Spain.

出版信息

Transplant Proc. 2006 Oct;38(8):2374-5. doi: 10.1016/j.transproceed.2006.08.036.

Abstract

The life expectancy of the current Spanish population is 78 years, with some 20% of the population aged over 65 years. The continuing increase in the demand for transplants has led to widening of the criteria for acceptance of donors without worsening the results, but without reducing transplant waiting lists or mortality. This has resulted in the need to include the concept of the expanded criteria donor (ECD). We undertook a retrospective study of 77 donors from a hospital with no neurosurgery service from January 2000 to December 2005. Four of the donors younger than 60 years of age (n = 38) were not appropriate (10.5%), whereas five of the donors older than 60 years of age (n = 39) were not appropriate (12.8%; P = NS). The older donors provided 47 used kidneys (60.2%) and 22 livers (56.4%), slightly fewer than those obtained from the younger donors, though the difference was not significant. Thus, ECDs, those older than 60 years of age, did not result in a significant loss of kidneys or livers available for transplantation. Other factors associated with systemic vascular disease and accompanying disorders could be determinant when predicting the usefulness of organs for transplantation.

摘要

目前西班牙人口的预期寿命为78岁,约20%的人口年龄超过65岁。移植需求的持续增加导致供体接受标准放宽,而结果并未恶化,但移植等待名单和死亡率并未降低。这就产生了纳入扩大标准供体(ECD)概念的必要性。我们对2000年1月至2005年12月期间一家没有神经外科服务的医院的77名供体进行了回顾性研究。38名年龄小于60岁的供体中有4名不合适(10.5%),而39名年龄大于60岁的供体中有5名不合适(12.8%;P=无统计学意义)。年龄较大的供体提供了47个可用肾脏(60.2%)和22个肝脏(56.4%),略少于年轻供体提供的数量,尽管差异不显著。因此,年龄大于60岁的ECD并未导致可用于移植的肾脏或肝脏显著减少。在预测器官移植的可用性时,与全身血管疾病及伴随疾病相关的其他因素可能起决定性作用。

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