Navarro A P, Sohrabi S, Wyrley-Birch H, Vijayanand D, Wilson C, Sanni A, Reddy M, Manas D, Rix D, Talbot D
Liver and Renal Transplant Unit, Freeman Hospital, Newcastle upon Tyne, United Kingdom.
Transplant Proc. 2006 Oct;38(8):2633-4. doi: 10.1016/j.transproceed.2006.08.006.
Kidneys transplanted from non-heart-beating donors (NHBD) are generally regarded as marginal or extended criteria grafts due to the associated period of warm ischemia. The most prolonged periods occurring in the category II (uncontrolled) donor. This potential for injury can adversely affect the glomular filtration rate (GFR), which in severe cases results in primary nonfunction. Viability testing can identify a group of kidneys that, although unsuitable for solitary transplantation, may be considered for dual transplant. This retrospective study examined a series of 11 dual renal transplants, comparing 3- and 12-month GFR outcome data with 81 single NHBD transplants. The mean GFR at 3 months in the dual group was 47.6 and at 12 months was 48.6. In the single group the GFR at 3 months was 40.6 and at 12 months was 41.9. Thus using viability testing to identify NHBD kidneys suitable for dual transplant appears reliable and predictable.
由于存在相关的热缺血期,来自非心脏跳动供体(NHBD)的移植肾通常被视为边缘性或扩大标准移植物。在II类(未控制)供体中出现的热缺血期最长。这种损伤可能性会对肾小球滤过率(GFR)产生不利影响,在严重情况下会导致原发性无功能。活力测试可以识别出一组肾脏,这些肾脏虽然不适合单独移植,但可考虑用于双肾移植。这项回顾性研究检查了一系列11例双肾移植病例,并将3个月和12个月时的GFR结果数据与81例单肾NHBD移植病例进行了比较。双肾移植组3个月时的平均GFR为47.6,12个月时为48.6。单肾移植组3个月时的GFR为40.6,12个月时为41.9。因此,使用活力测试来识别适合双肾移植的NHBD肾脏似乎是可靠且可预测的。