胸腺的独特性：T细胞的所有适宜条件。

Thymus exclusivity: all the right conditions for T cells.

作者信息

Iwasaki Hiromi, Akashi Koichi

机构信息

Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan.

出版信息

Immunity. 2006 Nov;25(5):697-700. doi: 10.1016/j.immuni.2006.10.005.

DOI:10.1016/j.immuni.2006.10.005

PMID:17098201

Abstract

A fraction of primitive "lymphoid" precursors retain plasticity for myeloid differentiation. In this issue of Immunity, Laiosa et al. describe that Notch-Delta signals can protect thymic precursors from reprogramming into the myeloid lineage, antagonizing the enforced myeloid transcription factors such as PU.1 and C/EBPalpha.

摘要

一小部分原始的“淋巴样”前体细胞保留了向髓系分化的可塑性。在本期《免疫》杂志中，莱奥萨等人描述了Notch-Delta信号可以保护胸腺前体细胞不被重编程为髓系谱系，拮抗诸如PU.1和C/EBPα等强制性髓系转录因子。