McGrath J, Murphy G M
Institute of Dermatology, St Thomas' Hospital, London, England.
Drugs. 1991 Feb;41(2):178-84. doi: 10.2165/00003495-199141020-00003.
For many years the exact nature of the pathophysiology of seborrhoeic dermatitis and dandruff was in doubt. Different schools of thought debated whether Pityrosporum yeasts were of primary pathogenic significance or a secondary phenomenon, with epidermal hyperproliferation as the primary pathology. Although effective therapy in seborrhoeic dermatitis and dandruff has for a long time been based on compounds whose only common link was antipityrosporal activity, proof of this relevance was lacking until the introduction of effective antifungal drugs, in particular ketoconazole. This article charts the swing of opinion towards the primary pityrosporal aetiology of seborrhoeic dermatitis and dandruff, reviews the evidence that antipityrosporal activity is the common link to various compounds which benefit these conditions, and compares the efficacy of these substances in treatment.
多年来，脂溢性皮炎和头皮屑的病理生理学的确切性质一直存在疑问。不同的学派争论马拉色菌酵母是具有主要致病意义还是一种继发现象，而表皮过度增殖才是主要病理。尽管长期以来脂溢性皮炎和头皮屑的有效治疗一直基于仅具有抗马拉色菌活性这一共同联系的化合物，但在有效抗真菌药物尤其是酮康唑问世之前，这种相关性的证据一直缺乏。本文阐述了关于脂溢性皮炎和头皮屑主要由马拉色菌病因引起这一观点的转变，回顾了抗马拉色菌活性是有益于这些病症的各种化合物的共同联系的证据，并比较了这些物质在治疗中的疗效。
