酮康唑和伊曲康唑对圆形糠秕孢子菌的体外及体内活性
In vitro and in vivo activities of ketoconazole and itraconazole against Pityrosporum orbiculare.
作者信息
Faergemann J
出版信息
Antimicrob Agents Chemother. 1984 Nov;26(5):773-4. doi: 10.1128/AAC.26.5.773.
Abstract
The MICs of ketoconazole and itraconazole against Pityrosporum orbiculare were 0.02 to 0.05 and 0.1 to 0.2 micrograms ml-1, respectively. In a rabbit model, orally administered ketoconazole (1 mg kg-1) afforded protection against experimental pityriasis (tinea) versicolor in all animals. Itraconazole (5 mg kg-1) was effective in four of five rabbits.
摘要
酮康唑和伊曲康唑对圆形糠秕孢子菌的最低抑菌浓度分别为0.02至0.05微克/毫升和0.1至0.2微克/毫升。在兔模型中，口服酮康唑（1毫克/千克）可使所有动物免受实验性花斑癣（癣）的侵害。伊曲康唑（5毫克/千克）在五只兔子中有四只有效。
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