Thomson J A, Chiu J F, Hnilica L S
Biochim Biophys Acta. 1975 Sep 12;407(1):114-9. doi: 10.1016/0005-2787(75)90029-5.
Nuclear phosphoprotein kinases from normal rat liver and transplantable neoplasms were fractionated and compared. A phosphoprotein kinase fraction activated by Mn2+ was found to be present only in the neoplasms. This nuclear protein kinase phosphorylated nuclear proteins represented by one major and several minor bands as determined by polyacrylamide gel electrophoresis (M approximately 50,000).
对来自正常大鼠肝脏和可移植肿瘤的核磷蛋白激酶进行了分级分离和比较。发现一种由Mn2+激活的磷蛋白激酶组分仅存在于肿瘤中。通过聚丙烯酰胺凝胶电泳测定，这种核蛋白激酶使以一条主要条带和几条次要条带为代表的核蛋白磷酸化（分子量约为50,000）。
