Cukrová V, Klamová H
Institute of Haematology and Blood Transfusion, Prague, CSFR.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1990;117(5):647-52.
Peripheral blood mononuclear cells of a patient with cyclic neutropenia release a high molecular weight substance (over 300,000) inhibiting normal CFU-GM cells to enter the S-phase of cell cycle. The inhibitor was released predominantly in the neutropenic phase of the disease, while in the period of normal granulocyte count the release was lower or undetectable. Also sensitivity of patient's bone marrow CFU-GM cells to similar high molecular weight inhibitor produced by ML-2 cell liner or to human placental ferritin varied within the disease cycle. CFU-GM in the normal granulocyte count period were sensitive to the inhibitors, but CFU-GM in the neutropenic phase were resistant.
周期性中性粒细胞减少症患者的外周血单个核细胞释放出一种高分子量物质（超过300,000），该物质可抑制正常的CFU-GM细胞进入细胞周期的S期。这种抑制剂主要在疾病的中性粒细胞减少期释放，而在粒细胞计数正常期间，其释放量较低或检测不到。此外，患者骨髓CFU-GM细胞对ML-2细胞系产生的类似高分子量抑制剂或人胎盘铁蛋白的敏感性在疾病周期内有所变化。粒细胞计数正常期间的CFU-GM对抑制剂敏感，但中性粒细胞减少期的CFU-GM具有抗性。
